Ige information

Unfortunately, we don't have much English information about Ige, but we have more information in other languages German, French, Italian, Spanish. Here is the automatic translation by Google:

As immunoglobulin E (IgE) is called an antibody that is to fend off parasites in the first place. He is also responsible for allergies. Of all the antibody isotypes IgE was detected as the last, namely until 1966, by the couple Kimishige and Teruko Ishizaka. This late discovery is explained by the comparatively very low concentrations of free IgE antibodies in the serum. While IgG antibodies are typically present in concentrations of 9 mg / ml of serum, the IgE levels are at about 30 ng / ml serum. IgE antibodies are the only predominantly cell-bound antibodies are present. The IgE has the ability to get through Fc receptors on mast cells or basophilic granulocytes bind to and remain there for many years in the body. It binds an allergen, it shall arrange for the mast cells to pour out substances that trigger allergies - mainly histamine. It makes up less than 1% of all immunoglobulins of the body and has the typical form of the Y, like the IgG or IgD, but a longer stem. Other classes of immunoglobulins in the human body, in addition to IgE and IgA, IgM, IgG and IgD. (...)

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